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Almost everybody knows you can use helium to make your voice sound funny... But what many people don't know is... It's also good for making bubblegum balloons!... I really wish I was one of the people who didn't know that...
Seriously though, don’t inhale helium. If done by a professional it isn’t that dangerous, but it can lead to death and brain damage if done wrong.
Interestingly, once I saw a science teacher inhale a gas that was heavier than air to make him sound like Darth Vader.